Dimethylformamide → 1,2-Difluoro-4-methoxy-5-nitrobenzene
반응식
[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([OH:9])=[C:4]([N+:10]([O-:12])=[O:11])[CH:3]=1.[C:13](=O)([O-])[O-].[K+].[K+].CN(C=O)C.IC>O>[F:1][C:2]1[CH:3]=[C:4]([N+:10]([O-:12])=[O:11])[C:5]([O:9][CH3:13])=[CH:6][C:7]=1[F:8]참가 물질
6
실험 절차
4,5-Difluoro-2-nitrophenol (INTERMEDIATE 51) (2.02 g, 11.54 mmol) and potassium carbonate (2.39 g, 17.3 mmol) were added into a 50 mL round-bottomed flask. DMF (10 mL) was added. Iodomethane (1.08 mL, 17.3 mmol) was added. The reaction mixture was stirred at RT overnight. The mixture was poured into water (60 mL) and stirred for 10 min. Filtration afforded the title product as a precipitate (1.9 g, 87% yield).
후처리
- stirringstirred for 10 min
- filtrationFiltration
출처 및 근거
- ORD 기록
- ord-e861ab369cf9464fbbbf7063492c228c
- 출처 데이터셋
- uspto-grants-2013_06
- 특허 번호
- US08461170B2
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