Potassium Carbonate → 1-(2-Chloropyridin-4-ylmethyl)-4-acetylpiperazine

HRID 1257110

반응식

HRID 1257110 반응식
[C:1]([N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)(=[O:3])[CH3:2].[Cl:10][C:11]1[CH:16]=[C:15]([CH2:17]Cl)[CH:14]=[CH:13][N:12]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Cl:10][C:11]1[CH:16]=[C:15]([CH2:17][N:7]2[CH2:8][CH2:9][N:4]([C:1](=[O:3])[CH3:2])[CH2:5][CH2:6]2)[CH:14]=[CH:13][N:12]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 837951-AcetylpiperazineHCID 111265732-Chloro-4-(chloromethyl)pyridine

생성물 1

HCID 582851821-(2-Chloropyridin-4-ylmethyl)-4-acetylpiperazine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

N-Acetylpiperazine (1.0 equiv) was mixed with compound 2-chloro-4-(chloro-methyl)pyridine (1.0 equiv) and K2CO3 (4 equiv) in DMF. The mixture was stirred for 1 h at rt. After removing most of the solvent, the residue was partitioned in water and EtOAc. The organic layer was separated, dried over anhydrous Na2SO4, and evaporated in vacuo. The residue was purified by flash chromatography to give the title compound as a solid.

후처리

  1. customAfter removing most of the solvent
  2. customthe residue was partitioned in water
  3. customThe organic layer was separated
  4. dry with materialdried over anhydrous Na2SO4
  5. customevaporated in vacuo
  6. customThe residue was purified by flash chromatography

출처 및 근거

ORD 기록
ord-99434ad2b24e4ade9640c921364c5de3
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08461339B2

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