Dimethylformamide → 3-(2-Methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoyl chloride

HRID 1257988노트

반응식

HRID 1257988 반응식
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[C:7]([CH3:19])=[C:8]([CH:12]=[CH:13][C:14]=1[S:15]([CH3:18])(=[O:17])=[O:16])[C:9](O)=[O:10].C(Cl)(=O)C([Cl:23])=O.CN(C=O)C>C(Cl)(Cl)Cl>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[C:7]([CH3:19])=[C:8]([CH:12]=[CH:13][C:14]=1[S:15]([CH3:18])(=[O:17])=[O:16])[C:9]([Cl:23])=[O:10]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 667565243-(2-Methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoic acid

생성물 1

HCID 866548323-(2-Methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoyl chloride수율 97.7%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

3-(2-Methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoic acid (500 mg) was dissolved in chloroform (20 mL), and oxalyl chloride (500 mg) and a catalytic amount of DMF were added, followed by stirring at room temperature for 3 hours. Under reduced pressure, the solvent and an excess reagent were distilled off to obtain 3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoyl chloride (520 mg) as an oily product.

후처리

  1. distillationUnder reduced pressure, the solvent and an excess reagent were distilled off

출처 및 근거

ORD 기록
ord-c074bbf761974e4a93545a977a7ec73d
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08466089B2

반응 노트

불러오는 중…