Sodium Dithionite → 5,6-Diamino-3-propylpyrimidine-2,4(1H,3H)-dione

HRID 1258026노트

반응식

HRID 1258026 반응식
[NH2:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH3:11])[C:4](=[O:12])[C:3]=1[N:13]=O.S(S([O-])=O)([O-])=O.[Na+].[Na+]>N>[NH2:13][C:3]1[C:4](=[O:12])[N:5]([CH2:9][CH2:10][CH3:11])[C:6](=[O:8])[NH:7][C:2]=1[NH2:1]

참가 물질

4

반응물 2

HCID 24489Sodium DithioniteHCID 144253236-Amino-5-nitroso-3-propylpyrimidine-2,4(1H,3H)-dione

생성물 1

HCID 109542025,6-Diamino-3-propylpyrimidine-2,4(1H,3H)-dione

시약·촉매·용매 1

HCID 222Ammonia용매

반응 조건

온도
5 °C

실험 절차

To a solution of 6-amino-5-nitroso-3-propyl-1,3-dihydropyrimidine-2,4-dione (5.4 g, 27 mmol) in 12.5% aqueous ammonia (135 ml) at 70° C. was added sodium dithionite (Na2S2O4, 9.45 g, 54 mmol) in portions over 15 minutes, and the mixture was stirred for 20 minutes. The solution was concentrated under reduced pressure, cooled to 5° C., the precipitate filtered off, and washed with cold water, to provide 5,6-diamino-3-propyl-1,3-dihydropyrimidine-2,4-dione, a compound of formula (12).

후처리

  1. concentrationThe solution was concentrated under reduced pressure
  2. filtrationthe precipitate filtered off
  3. washwashed with cold water

출처 및 근거

ORD 기록
ord-f42deebcd1ac4ea188d977a3c035fe90
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08466129B2

반응 노트

불러오는 중…