Sodium Dithionite → 5,6-Diamino-1-ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

HRID 1258030

반응식

HRID 1258030 반응식
[NH2:1][C:2]1[N:7]([CH2:8][CH3:9])[C:6](=[O:10])[NH:5][C:4](=[O:11])[C:3]=1[N:12]=O.S(S([O-])=O)([O-])=O.[Na+].[Na+]>N>[NH2:12][C:3]1[C:4](=[O:11])[NH:5][C:6](=[O:10])[N:7]([CH2:8][CH3:9])[C:2]=1[NH2:1]

참가 물질

4

반응물 2

HCID 24489Sodium DithioniteHCID 3005096-Amino-1-ethyl-5-nitroso-1,3-dihydropyrimidine-2,4-dione

생성물 1

HCID 219163605,6-Diamino-1-ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

시약·촉매·용매 1

HCID 222Ammonia용매

반응 조건

온도
5 °C

실험 절차

To a solution of 6-amino-1-ethyl-5-nitroso-1,3-dihydropyrimidine-2,4-dione (3.9 g, 21.2 mmol) in 14.5% aqueous ammonia (50 ml) at 50° C. was added sodium dithionite (Na2S2O4, 7.37 g, 42.4 mmol) in portions over 15 minutes, and the mixture was stirred for 20 minutes. The solution was concentrated under reduced pressure to a volume of 30 ml, cooled to 5° C., the precipitate filtered off, and washed with cold water, to provide 5,6-diamino-1-ethyl-1,3-dihydropyrimidine-2,4-dione, a compound of formula (15).

후처리

  1. concentrationThe solution was concentrated under reduced pressure to a volume of 30 ml
  2. filtrationthe precipitate filtered off
  3. washwashed with cold water

출처 및 근거

ORD 기록
ord-541aa4af663f44629fd84555ec6bbb02
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08466129B2

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