Hydrochloric Acid → (4-Methoxy-5-methyl-2-nitrophenyl)acetonitrile
반응식
COC(=O)[CH:4]([C:17]#[N:18])[C:5]1[CH:10]=[C:9]([CH3:11])[C:8]([O:12][CH3:13])=[CH:7][C:6]=1[N+:14]([O-:16])=[O:15].Cl>CO>[CH3:13][O:12][C:8]1[C:9]([CH3:11])=[CH:10][C:5]([CH2:4][C:17]#[N:18])=[C:6]([N+:14]([O-:16])=[O:15])[CH:7]=1참가 물질
4
실험 절차
To a solution of cyano-(4-methoxy-5-methyl-2-nitrophenyl)acetic acid methyl ester in methanol (1.7 mL) was added 6 mol/L hydrochloric acid (1.7 mL), and this mixture was heated under reflux for 9 hours. After cooling to ambient temperature, this organic solvent was removed under reduced pressure and resulting mixture was extracted with ethyl acetate. The residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate) to give the title compound (0.25 g).
후처리
- temperaturethis mixture was heated
- temperatureunder reflux for 9 hours
- customthis organic solvent was removed under reduced pressure
- customresulting mixture
- extractionwas extracted with ethyl acetate
- customThe residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate)
출처 및 근거
- ORD 기록
- ord-95c58dcc83f34341b29b382556342f58
- 출처 데이터셋
- uspto-grants-2013_06
- 특허 번호
- US08466152B2
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