Acetic Acid → 3-Amino-2,4-dichlorobenzoic acid

HRID 1258646노트

반응식

HRID 1258646 반응식
C([NH:4][C:5]1[C:6]([Cl:15])=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9])(=O)C.C(O)(=O)C>Cl>[NH2:4][C:5]1[C:6]([Cl:15])=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9]

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 198331103-Acetamido-2,4-dichlorobenzoic acid

생성물 1

HCID 152782343-Amino-2,4-dichlorobenzoic acid

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

3-Acetylamino-2,4-dichloro-benzoic acid (21.0 g, 84.6 mmol) was stirred in 6 M aq. HCl-solution (120 mL) and acetic acid (250 mL) at reflux for 24 h. The reaction mixture was cooled, concentrated, diluted with water and concentrated again. The residue was diluted with water, stirred under cooling and filtered. The filtercake was washed and dried to give the sub-title compound.

후처리

  1. temperatureThe reaction mixture was cooled
  2. concentrationconcentrated
  3. additiondiluted with water
  4. concentrationconcentrated again
  5. additionThe residue was diluted with water
  6. temperatureunder cooling
  7. filtrationfiltered
  8. washThe filtercake was washed
  9. customdried

출처 및 근거

ORD 기록
ord-b48597ec34394e1e8283ebe92fde53a7
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08466186B2

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