HCID 67959596, 화합물 → HCID 67957634, 화합물

HRID 1258712노트

반응식

HRID 1258712 반응식
[F:1][C:2]1[C:9]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]([F:19])([F:18])[F:17])[CH2:12][CH2:11]2)=[CH:8][C:5]([NH:6][CH3:7])=[C:4]([N+:20]([O-])=O)[CH:3]=1>[Ni].C1COCC1>[F:1][C:2]1[C:9]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]([F:19])([F:18])[F:17])[CH2:12][CH2:11]2)=[CH:8][C:5]([NH:6][CH3:7])=[C:4]([CH:3]=1)[NH2:20]

참가 물질

4

반응물 1

HCID 67959596HCID 67959596, 화합물

생성물 1

HCID 67957634HCID 67957634, 화합물

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 4-fluoro-N-methyl-2-nitro-5-(4-trifluoromethyl-piperidin-1-yl)aniline (200 mg, 0.62 mmol), Ra—Ni (4 mg, 0.062 mmol) and THF (30 mL) was shaken under H2 atmosphere (1 atm) at rt for 1 h. The mixture was filtered through celite and the celite pad was further washed with THF. Concentration and crystallization from Et2O/PE gave the sub-title compound.

후처리

  1. filtrationThe mixture was filtered through celite
  2. washthe celite pad was further washed with THF
  3. concentrationConcentration and crystallization from Et2O/PE

출처 및 근거

ORD 기록
ord-b770fef46c39472d8751d52cce834a09
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08466186B2

반응 노트

불러오는 중…