N-(4-chloro-3-fluoro-5-nitrobenzyl)-1-trifluoromethyl-cyclopropanecarboxamide → N-(3-Amino-4-chloro-5-fluoro-benzyl)-1-trifluoromethyl-cyclopropanecarboxamide

HRID 1258744노트

반응식

HRID 1258744 반응식
[Cl:1][C:2]1[C:18]([N+:19]([O-])=O)=[CH:17][C:5]([CH2:6][NH:7][C:8]([C:10]2([C:13]([F:16])([F:15])[F:14])[CH2:12][CH2:11]2)=[O:9])=[CH:4][C:3]=1[F:22]>[Ni].C1COCC1>[NH2:19][C:18]1[CH:17]=[C:5]([CH:4]=[C:3]([F:22])[C:2]=1[Cl:1])[CH2:6][NH:7][C:8]([C:10]1([C:13]([F:14])([F:15])[F:16])[CH2:11][CH2:12]1)=[O:9]

참가 물질

4

반응물 1

HCID 67959823N-(4-chloro-3-fluoro-5-nitrobenzyl)-1-trifluoromethyl-cyclopropanecarboxamide

생성물 1

HCID 67975171N-(3-Amino-4-chloro-5-fluoro-benzyl)-1-trifluoromethyl-cyclopropanecarboxamide

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매

실험 절차

H2 was passed through a shaken mixture of N-(4-chloro-3-fluoro-5-nitrobenzyl)-1-trifluoromethyl-cyclopropanecarboxamide (980 mg, 2.88 mmol), Ra—Ni (17 mg, 0.29 mmol) and THF (50 mL) at rt for 1.5 h. The mixture was filtered through celite and concentrated.

후처리

  1. filtrationThe mixture was filtered through celite and
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-af6c8d8bf04e4102a44a172d28fcb01b
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08466186B2

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