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1,2-Dichloroethane → HCID 178447333, 화합물

HRID 1258750
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HRID 1258750 반응식
[N:1]([C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:17]=1[O:18][C:19]([F:22])([F:21])[F:20])[CH2:7][NH:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])=[C:2]=S.[NH2:23][C:24]1[C:31]([NH2:32])=[CH:30][C:27]([C:28]#[N:29])=[C:26]([N:33]2[CH2:38][CH2:37][CH2:36][CH:35]([C:39]([F:42])([F:41])[F:40])[CH2:34]2)[CH:25]=1.CN(C=O)C.C(Cl)CCl>C(Cl)(Cl)Cl.O>[C:28]([C:27]1[C:26]([N:33]2[CH2:38][CH2:37][CH2:36][CH:35]([C:39]([F:42])([F:40])[F:41])[CH2:34]2)=[CH:25][C:24]2[NH:23][C:2]([NH:1][C:4]3[CH:5]=[C:6]([CH:15]=[CH:16][C:17]=3[O:18][C:19]([F:22])([F:21])[F:20])[CH2:7][NH:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])=[N:32][C:31]=2[CH:30]=1)#[N:29]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 111,2-DichloroethaneHCID 6228DimethylformamideHCID 679577914,5-Diamino-2-(3-trifluoromethyl-piperidin-1-yl)benzonitrileHCID 86674354N-(3-Isothiocyanato-4-trifluoromethoxy-benzyl)-2,2-dimethyl-propionamide

생성물 1

HCID 178447333HCID 178447333, 화합물

시약·촉매·용매 2

HCID 962
Water
용매
HCID 6212Chloroform용매

실험 절차

A mixture of N-(3-isothiocyanato-4-trifluoromethoxy-benzyl)-2,2-dimethyl-propionamide (135 mg, 0.406 mmol), 4,5-diamino-2-(3-trifluoromethyl-piperidin-1-yl)benzonitrile (115 mg, 0.406 mmol) and DMF (2 mL) was stirred at rt for 4 h. EDC (101 mg, 0.527 mmol) was added and mixture was stirred at rt overnight. The mixture was treated with water and extracted with Et2O. Concentration and purification by column chromatography gave an oil. The oil was treated with CHCl3 and the precipitate was collected by filtration.

후처리

  1. stirringmixture was stirred at rt overnight
  2. extractionextracted with Et2O
  3. concentrationConcentration and purification by column chromatography
  4. customgave an oil
  5. filtrationthe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-1ca4f1d92d9d43c5be95592e6fc7dbab
출처 데이터셋
uspto-grants-2013_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08466186B2

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