Sodium Chloride → 2-Bromoquinoline-4-carboxylic acid

반응식

P(Br)(Br)([Br:3])=O.O[C:7]1[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=1.[Cl-].[Na+]>>[Br:3][C:7]1[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=1

참가 물질

반응물 3

HCID 5234Sodium Chloride

HCID 24613Phosphorus oxybromide

HCID 178524625HCID 178524625, 화합물

생성물 1

HCID 155506972-Bromoquinoline-4-carboxylic acid

반응 조건

온도: 90 °C

실험 절차

Phosphorus oxybromide (5.00 g, 17.4 mmol) was added to commercially available 2-hydroxy-4-quinolinecarboxylic acid (1.00 g, 5.29 mmol), and the mixture was heated with stirring at 90° C. for 4 hours. The reaction solution was added to ice water. To the mixture, sodium chloride was added, and the deposited crystal was collected by filtration, washed with water, and dried to obtain the title compound.