N-bromobutanimide → Methyl 5-bromo-1H-pyrrole-2-carboxylate
반응식
COCCCC[N:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[C:12]([O:14][CH3:15])=[O:13].[Br:16]N1C(=O)CCC1=O>ClCCl>[Br:16][C:11]1[NH:7][C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:9][CH:10]=1참가 물질
4
실험 절차
Methyl 1-(4-methoxybutyl)-1H-pyrrole-2-carboxylate (4.5 g) was dissolved in dichloromethane (30 ml), N-bromosuccinimide (4.0 g) was added and the mixture was stirred for 1 hr. The reaction mixture was washed successively with water and brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography, and a fraction eluted with ethyl acetate-hexane (1:4) was concentrated under reduced pressure to give the object product (2.2 g).
후처리
- washThe reaction mixture was washed successively with water and brine
- dry with materialdried over anhydrous sodium sulfate
- customThe solvent was evaporated under reduced pressure
- washa fraction eluted with ethyl acetate-hexane (1:4)
- concentrationwas concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-237a70aed8d440cda747cc04c8efd5ed
- 출처 데이터셋
- uspto-grants-2013_06
- 특허 번호
- US08466282B2
반응 노트
불러오는 중…