Ethanol → KMUP-1 Nicotinic acid

HRID 1260166노트

반응식

HRID 1260166 반응식
[CH3:1][N:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:5](=[O:6])[C:4]2[N:11]([CH2:14][CH2:15][N:16]3[CH2:21][CH2:20][N:19]([C:22]4[C:27]([Cl:28])=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:18][CH2:17]3)[CH:12]=[N:13][C:3]1=2.C[OH:30].[CH2:31]([OH:33])[CH3:32]>C(O)(=O)C1C=CC=NC=1>[CH3:1][N:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:5](=[O:6])[C:4]2[N:11]([CH2:14][CH2:15][N:16]3[CH2:21][CH2:20][N:19]([C:22]4[C:27]([Cl:28])=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:18][CH2:17]3)[CH:12]=[N:13][C:3]1=2.[C:31]([OH:30])(=[O:33])[C:32]1[CH:5]=[CH:4][CH:3]=[N:2][CH:1]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 887MethanolHCID 10453764Kmup 1

생성물 1

HCID 51039835KMUP-1 Nicotinic acid

시약·촉매·용매 1

HCID 938Nicotinic Acid용매

실험 절차

KMUP-1 (8.0 g) is dissolved in a mixture of ethanol (10 mL) and nicotinic acid (2.4 g) and reacted at 50° C. for 20 min, the methanol is added thereinto under room temperature and the solution is incubated over night for crystallization and filtrated to obtain KMUP-1-Nicotinic acid salt (8.3 g).

후처리

  1. customreacted at 50° C. for 20 min
  2. customunder room temperature and the solution is incubated over night for crystallization
  3. filtrationfiltrated

출처 및 근거

ORD 기록
ord-72f38d681114404db802a736be8234bd
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470805B2

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