Hydrochloric Acid → 2-Pyridin-2-yl-thiazol-5-ylamine

HRID 1260324노트

반응식

HRID 1260324 반응식
C(OC(=O)[NH:7][C:8]1[S:12][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)=[N:10][CH:9]=1)(C)(C)C.Cl>O1CCOCC1>[N:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[C:11]1[S:12][C:8]([NH2:7])=[CH:9][N:10]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67299899(2-Pyridin-2-yl-thiazol-5-yl)-carbamic acid tert-butyl ester

생성물 1

HCID 457887092-Pyridin-2-yl-thiazol-5-ylamine수율 61.1%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

A solution of (2-pyridin-2-yl-thiazol-5-yl)-carbamic acid tert-butyl ester (200 mg, 0.72 mmol) in dioxane (3 ml) was treated with 4M HCl in dioxane (3 ml) and the resulting suspension was stirred at ambient temperature overnight. The reaction mixture was filtrated and the precipitate was dissolved in sodium hydroxide (20 ml, 0.5M aqueous solution) and extracted with dichloromethane. The combined organic phases were dried and the solvent was evaporated to yield the product as orange solid (78 mg, 60%) which was used without any further purification. MS: M=178.1 (M+H)+

후처리

  1. filtrationThe reaction mixture was filtrated
  2. dissolutionthe precipitate was dissolved in sodium hydroxide (20 ml, 0.5M aqueous solution)
  3. extractionextracted with dichloromethane
  4. customThe combined organic phases were dried
  5. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-541a556610bf41adbb89e0bba3fa2393
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470820B2

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