Lithium Hydroxide → Methylsuccinic acid

HRID 1260407

반응식

HRID 1260407 반응식
[CH3:1][CH:2]([CH2:7][C:8]([O:10]C)=[O:9])[C:3]([O:5]C)=[O:4].[OH-].[Li+]>O1CCCC1.O>[CH3:1][CH:2]([CH2:7][C:8]([OH:10])=[O:9])[C:3]([OH:5])=[O:4]

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 15350Butanedioic acid, 2-methyl-, 1,4-dimethyl ester

생성물 1

HCID 10349Methylsuccinic acid

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
40 °C

실험 절차

Commercially available dimethyl methylsuccinate (1.57 g, 9.8 mmol) was dissolved in a 3:1 mixed solvent of tetrahydrofuran and water, and lithium hydroxide (4 g, 98 mmol) was added and stirred for 2 days at 40° C. under reflux. After completion of the reaction was confirmed by TLC, the residue was distilled under reduced pressure to afford the title compound.

후처리

  1. additionwas added
  2. temperatureunder reflux
  3. distillationthe residue was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-5c1c95c30a16424cb4d6a70811034722
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470836B2

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