홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Diisopropylethylamine → tert-butyl 1,3-dioxo-2-[trans-2-phenylcyclopropyl]hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate

HRID 1260463
노트
인쇄 미리보기

반응식

HRID 1260463 반응식
[N:1]1([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:6][CH2:5][NH:4][CH:3]([C:7]([O:9]C)=O)[CH2:2]1.[C:18]1([C@@H:24]2[CH2:26][C@H:25]2[N:27]=[C:28]=[O:29])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.CCN(C(C)C)C(C)C>C1(C)C=CC=CC=1>[O:9]=[C:7]1[CH:3]2[CH2:2][N:1]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:6][CH2:5][N:4]2[C:28](=[O:29])[N:27]1[C@@H:25]1[CH2:26][C@H:24]1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 255285trans-2-Phenylcyclopropyl isocyanateHCID 27568191-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate

생성물 1

HCID 67300259tert-butyl 1,3-dioxo-2-[trans-2-phenylcyclopropyl]hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate수율 60%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To A3 in toluene (0.4M) was added dropwise trans-2-phenylcyclopropyl isocyanate (1.05 eq.). The mixture was stirred O/N at rt. DIPEA (1.5 eq.) was added and the mixture refluxed for 20 h. The organic phase was washed with phosphate buffer (2×200 mL, 0.75 M NaH2PO4, pH˜4.5) and the solvent removed under reduced pressure. The residue was purified by column chromatography on silica gel, eluting with 20-100% EtOAc/petroleum ether to give the title compound in 60% yield. MS (ES+) C20H25N3O4 requires 371, found: 394 (M+Na)+.

후처리

  1. temperaturethe mixture refluxed for 20 h
  2. washThe organic phase was washed with phosphate buffer (2×200 mL, 0.75 M NaH2PO4, pH˜4.5)
  3. customthe solvent removed under reduced pressure
  4. customThe residue was purified by column chromatography on silica gel
  5. washeluting with 20-100% EtOAc/petroleum ether

출처 및 근거

ORD 기록
ord-b5e88df092df44849a39f0f0487209d7
출처 데이터셋
uspto-grants-2013_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08470823B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트