1-Bromopropane → N-{1-Methyl-3-[4-(5-propoxypyridin-2-yloxy)phenyl]propyl}acetamide

반응식

[OH:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])=[CH:11][CH:10]=2)=[N:6][CH:7]=1.Br[CH2:24][CH2:25][CH3:26]>>[CH3:18][CH:17]([NH:19][C:20](=[O:22])[CH3:21])[CH2:16][CH2:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][C:5]2[CH:4]=[CH:3][C:2]([O:1][CH2:24][CH2:25][CH3:26])=[CH:7][N:6]=2)=[CH:10][CH:11]=1

참가 물질

반응물 2

HCID 78401-Bromopropane

HCID 67302795N-{3-[4-(5-Hydroxypyridin-2-yloxy)phenyl]-1-methylpropyl}acetamide

생성물 1

HCID 44608624N-{1-Methyl-3-[4-(5-propoxypyridin-2-yloxy)phenyl]propyl}acetamide

실험 절차

N-{3-[4-(5-Hydroxypyridin-2-yloxy)phenyl]-1-methylpropyl}acetamide was reacted with 1-bromopropane in analogy to example 10b. Yield: 38 mg (66%), M+H+: 343.13.

출처 및 근거

ORD 기록: ord-ba55ffdc906a4109bc005451be892b56
출처 데이터셋: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08470841B2

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