2-Chloro-4-fluorobenzaldehyde → 2-Chloro-4-(methylsulfonyl)benzaldehyde

HRID 1260629

반응식

HRID 1260629 반응식
[Cl:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:11][S:12]([O-:14])=[O:13].[Na+]>CS(C)=O>[Cl:1][C:2]1[CH:9]=[C:8]([S:12]([CH3:11])(=[O:14])=[O:13])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

참가 물질

4

반응물 2

HCID 1450242-Chloro-4-fluorobenzaldehydeHCID 2733271Sodium methanesulfinate

생성물 1

HCID 27610842-Chloro-4-(methylsulfonyl)benzaldehyde

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
90 °C

실험 절차

A suspension of 2-chloro-4-fluorobenzaldehyde (24.9 g, 0.16 mol) and dry sodium methanesulfinate (17.9 g, 0.175 mmol) in dry DMSO (60 ml) is stirred at 90° C. overnight. The reaction mixture is allowed to cool to room temperature and then poured onto ice-water (400 ml). The resulting precipitated is collected by filtration and dried under high vacuum to yield the titled compound as a yellow powder.

후처리

  1. temperatureto cool to room temperature
  2. additionpoured onto ice-water (400 ml)
  3. customThe resulting precipitated
  4. filtrationis collected by filtration
  5. customdried under high vacuum

출처 및 근거

ORD 기록
ord-98ea714a4cc0460797db4ad8ce7cef09
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470848B2

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