Sodium Hydroxide → 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-2-Methyl-

HRID 1260652노트

반응식

HRID 1260652 반응식
COC([N:5]1[C:9]2=[N:10][C:11]([Cl:14])=[CH:12][CH:13]=[C:8]2[CH:7]=[C:6]1[CH3:15])=O.[OH-].[Na+]>CO>[Cl:14][C:11]1[N:10]=[C:9]2[NH:5][C:6]([CH3:15])=[CH:7][C:8]2=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 73013581HCID 73013581, 화합물

생성물 1

HCID 210617341H-Pyrrolo[2,3-b]pyridine, 6-chloro-2-Methyl-

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

6-Chloro-2-methyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid methyl ester (0.225 g, 1 mmol) is dissolved in methanol (30 ml) and 1M NaOH (10 ml) and stirred at room temperature overnight. The methanol is removed in vacuo and the resulting white suspension is extracted with chloroform (3×20 ml), dried (MgSO4) and concentrated in vacuo to yield a white powder which is dried under high vacuum to yield the titled product. (MH+ 167).

후처리

  1. customThe methanol is removed in vacuo
  2. extractionthe resulting white suspension is extracted with chloroform (3×20 ml)
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated in vacuo
  5. customto yield a white powder which
  6. customis dried under high vacuum

출처 및 근거

ORD 기록
ord-4ae34c72b2d845f69495281f9076dccb
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470848B2

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