Phosphorus tribromide → 5-(Bromomethyl)-1-methyl-1H-benzotriazole

HRID 1260657노트

반응식

HRID 1260657 반응식
P(Br)(Br)[Br:2].[CH3:5][N:6]1[C:10]2[CH:11]=[CH:12][C:13]([CH2:15]O)=[CH:14][C:9]=2[N:8]=[N:7]1>C(OCC)C.O>[Br:2][CH2:15][C:13]1[CH:12]=[CH:11][C:10]2[N:6]([CH3:5])[N:7]=[N:8][C:9]=2[CH:14]=1

참가 물질

5

반응물 2

HCID 24614Phosphorus tribromideHCID 2776552(1-methyl-1H-1,2,3-benzotriazol-5-yl)methanol

생성물 1

HCID 27954185-(Bromomethyl)-1-methyl-1H-benzotriazole

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

Phosphorus tribromide (0.230 ml, 2.45 mmol) is added to a stirred solution of (1-methyl-1H-1,2,3-benzotriazole-5-yl)methanol (0.4 g, 2.45 mmol) in diethyl ether (25 ml) under an inert atmosphere of Argon. After stirring overnight at room temperature, the reaction mixture is diluted with water (5 ml) and stirred vigorously for 10 minutes. The organic portion is separated, washed with water (2×5 ml), brine (2×5 ml) and concentrated in vacuo to yield the titled product which is used crude in the next step. (MH+ 226).

후처리

  1. stirringstirred vigorously for 10 minutes
  2. customThe organic portion is separated
  3. washwashed with water (2×5 ml), brine (2×5 ml)
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-68dc7baab7654b5d9086a695af0b34e3
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470848B2

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