Sodium Hydroxide → 1-(Cyclopropylcarbonyl)piperidine-4-carboxylic acid

HRID 1260965

반응식

HRID 1260965 반응식
[CH:1]1([C:4]([N:6]2[CH2:11][CH2:10][CH:9]([C:12]([O:14]CC)=[O:13])[CH2:8][CH2:7]2)=[O:5])[CH2:3][CH2:2]1.[OH-].[Na+]>C(O)C>[CH:1]1([C:4]([N:6]2[CH2:7][CH2:8][CH:9]([C:12]([OH:14])=[O:13])[CH2:10][CH2:11]2)=[O:5])[CH2:2][CH2:3]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 10036613Ethyl 1-(cyclopropylcarbonyl)piperidine-4-carboxylate

생성물 1

HCID 89029151-(Cyclopropylcarbonyl)piperidine-4-carboxylic acid수율 95%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of the compound (6.3 g) obtained in step 4 in ethanol (30 mL) was added 4N aqueous sodium hydroxide solution (35 mL), and the mixture was stirred at room temperature for 22 hr. The reaction mixture was concentrated under reduced pressure, and made acidic with 6N hydrochloric acid. The resultant product was extracted with ethyl acetate, the organic layer was washed with brine and dried, and the solvent was evaporated under reduced pressure to give 1-(cyclopropylcarbonyl)piperidine-4-carboxylic acid (5.21 g, 95%) as a pale yellow powder.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. extractionThe resultant product was extracted with ethyl acetate
  3. washthe organic layer was washed with brine
  4. customdried
  5. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-6cd70335563140fd9ea2cbe21af12742
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470816B2

연결된 노트

불러오는 중…