Hydrochloric Acid → Methyl 3-(chlorocarbonyl)-5-nitrobenzoate

HRID 1261181노트

반응식

HRID 1261181 반응식
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[CH:10]=[C:6]([C:7](O)=[O:8])[CH:5]=1.[ClH:17]>S(Cl)(Cl)=O>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[CH:10]=[C:6]([C:7]([Cl:17])=[O:8])[CH:5]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 747761,3-Benzenedicarboxylic acid, 5-nitro-, 1-methyl ester

생성물 1

HCID 74774Methyl 3-(chlorocarbonyl)-5-nitrobenzoate

시약·촉매·용매 1

HCID 24386Thionyl Chloride용매

실험 절차

A suspension of 5-nitro-isophthalic acid mono methyl ester (22.52 g, 100.0 mmol) in thionyl chloride (50 ml) was heated to reflux for 6 hours (until the production of SO2 and HCl-gas ceased). The excess of thionyl chloride was removed under reduced pressure, the residue was dissolved in DCM and the product was precipitated by addition of hexane to give a white solid. Yield: 24.10 g (99%).

후처리

  1. temperaturewas heated
  2. customThe excess of thionyl chloride was removed under reduced pressure
  3. dissolutionthe residue was dissolved in DCM
  4. customthe product was precipitated by addition of hexane
  5. customto give a white solid

출처 및 근거

ORD 기록
ord-0fba3e45dacc44129240e3da748448cb
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470860B2

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