Hydrochloric Acid → 7-Chlorothieno[3,2-b]pyridine-2-carbaldehyde oxime

HRID 1261243노트

반응식

HRID 1261243 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([CH:11]=O)[S:10][C:3]=12.[NH2:13][OH:14].Cl>CO.O>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([CH:11]=[N:13][OH:14])[S:10][C:3]=12

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 787HydroxylamineHCID 509888497-Chlorothieno[3,2-b]pyridine-2-carbaldehyde

생성물 1

HCID 1363351767-Chlorothieno[3,2-b]pyridine-2-carbaldehyde oxime수율 85%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of aldehyde 14 (scheme 3) in MeOH was added NH2OH×HCl (227 mg, 3.26 mmol) in water (0.5 mL) and the mixture was stirred at room temperature for 0.5 h. The solvents were removed by under reduced pressure and the residue was partitioned between EtOAc and water. The organic phase was dried over anhydrous sodium sulfate, filtered and evaporated to dryness to afford the title compound 125 (458 mg, 85% yield) as a white solid. MS (m/z) 213.1/215.1 (M+H).

후처리

  1. customThe solvents were removed by under reduced pressure
  2. customthe residue was partitioned between EtOAc and water
  3. dry with materialThe organic phase was dried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-dc0fd0ca9d3344e79369c1f8faf8365b
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470850B2

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