Cyclopentanone → 1-(propan-2-yl)cyclopentanol

HRID 1261559노트

반응식

HRID 1261559 반응식
[CH:1]([Mg]Cl)([CH3:3])[CH3:2].[C:6]1(=[O:11])[CH2:10][CH2:9][CH2:8][CH2:7]1>>[CH:1]([C:6]1([OH:11])[CH2:10][CH2:9][CH2:8][CH2:7]1)([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 8452CyclopentanoneHCID 178418918HCID 178418918, 화합물

생성물 1

HCID 2440031-(propan-2-yl)cyclopentanol

실험 절차

According to Example 2, i-PrMgCl (3.30 mL; 3.30 mmol; 1.10 equiv) was reacted with cyclopentanone (252 mg; 3.00 mmol) in the presence of LaCl3.2LiCl (0.33 M; 9.09 mL, 3.00 mmol, 1.00 equiv), the conversion was complete after 5 min (GC monitoring). After workup and careful evaporation of the solvents under reduced pressure, the desired product was obtained as colorless oil (353 mg, 92%). The analytical data were found to be in accordance with the literature data.

후처리

  1. customAfter workup and careful evaporation of the solvents under reduced pressure

출처 및 근거

ORD 기록
ord-494c364158d64ef2b3bc6bebef270d5e
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470982B2

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