Hydrochloric Acid → 2-Methyl-1-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-2-ol

HRID 1261955노트

반응식

HRID 1261955 반응식
[N+](C1C=C(N2CCNCC2)C=CC=1)([O-])=O.[CH3:16][C:17]([OH:35])([CH3:34])[CH2:18][N:19]1[CH2:24][CH2:23][N:22]([C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([N+:31]([O-:33])=[O:32])[CH:26]=2)[CH2:21][CH2:20]1.Cl.O1C(C)(C)C1.C(Cl)Cl.CO>CO>[CH3:34][C:17]([OH:35])([CH3:16])[CH2:18][N:19]1[CH2:20][CH2:21][N:22]([C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([N+:31]([O-:33])=[O:32])[CH:26]=2)[CH2:23][CH2:24]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 11208Isobutylene oxideHCID 21226129Dichloromethane methanolHCID 866616672-Methyl-1-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-2-ol 1-(3-Nitro-phenyl)-piperazine

생성물 1

HCID 632395022-Methyl-1-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-2-ol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-Methyl-1-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-2-ol 1-(3-Nitro-phenyl)-piperazine; hydrochloride (2.0 g, 0.0082 mol) was dissolved in Methanol (42.5 mL) and the reaction mixture was placed in a sealed tube. 1,2-epoxy-2-methylpropane (0.888 g, 0.0123 mol) was then added at room temperature and the reaction was allowed to stir overnight. The mixture was then reduced en vacuo and the product was isolated by Isco flash column chromatography (DCM/MeOH) to afford 1.60 grams of 2-Methyl-1-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-2-ol as a yellow powder.

후처리

  1. customthe reaction mixture was placed in a sealed tube

출처 및 근거

ORD 기록
ord-1bdcca8675574905a11299be83036eb7
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08471005B2

반응 노트

불러오는 중…