Hydrochloric Acid → (5-Amino-1H-benzo[d]imidazol-2-yl)methanol

HRID 1262226노트

반응식

HRID 1262226 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:11]=[C:10]([CH2:12][OH:13])[NH:9][C:8]=2[CH:14]=1)([O-])=O.Cl>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[N:11]=[C:10]([CH2:12][OH:13])[NH:9][C:8]=2[CH:14]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 3744471(5-nitro-1H-1,3-benzodiazol-2-yl)methanol

생성물 1

HCID 838521(5-Amino-1H-benzo[d]imidazol-2-yl)methanol

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매2회

실험 절차

(6-Nitro-1H-benzoimidazol-2-yl)-methanol (1.00 g, 5.18 mmol) was dissolved in methanol (50.0 mL) and 3.00 M hydrogen chloride in methanol (8.63 mL, 25.9 mmol). 10% Palladium on Carbon (50% wet) (55.1 mg, 0.0259 mmol) was added and the reaction was hydrogenated at 40 psi. for 3 hours. The reaction was then filtered through celite to remove the catalyst and then concentrated under reduced pressure to obtain (6-Amino-1H-benzoimidazol-2-yl)-methanol; dihydrochloride as a brown foam (1.13 g, 92%). Product is used without further purification.

후처리

  1. filtrationThe reaction was then filtered through celite
  2. customto remove the catalyst
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-3e37874da161458d83c67c4b7d40e847
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08471005B2

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