Methyl iodide → 6-Bromo-2-methylsulfanyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

HRID 1262278노트

반응식

HRID 1262278 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[N:9]([CH:10]=1)[NH:8][C:7](=[S:11])[NH:6][C:5]2=[O:12].[CH3:13]I>O1CCCC1>[Br:1][C:2]1[CH:3]=[C:4]2[N:9]([CH:10]=1)[N:8]=[C:7]([S:11][CH3:13])[NH:6][C:5]2=[O:12]

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 574161296-Bromo-2-sulfanylidene-2,3-dihydropyrrolo[2,1-f][1,2,4]triazin-4(1H)-one

생성물 1

HCID 1363603016-Bromo-2-methylsulfanyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
45 °C

실험 절차

Into a round bottom flask, 6-Bromo-2-thioxo-2,3-dihydro-1H-pyrrolo[2,1-f][1,2,4]triazin-4-one (11.20 g, 0.04551 mol), Tetrahydrofuran (200 mL) and Methyl iodide (6.517 mL, 0.1047 mol) were added, respectively. The reaction was stirred at 45° C. for one hour. The solid was filtered. The solvent was removed under vacuum to give a solid. The combined solid was partitioned with water (500 mL) and saturated NaHCO3 (500 mL). The mixture was stirred for 30 minutes. The solid was filtered and washed with water to give 6-Bromo-2-methylsulfanyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one as a white solid (5.80, 49%).

후처리

  1. filtrationThe solid was filtered
  2. customThe solvent was removed under vacuum
  3. customto give a solid
  4. customThe combined solid was partitioned with water (500 mL) and saturated NaHCO3 (500 mL)
  5. stirringThe mixture was stirred for 30 minutes
  6. filtrationThe solid was filtered
  7. washwashed with water

출처 및 근거

ORD 기록
ord-c784874467094115b86f8cc95e451658
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08471005B2

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