Dimethylformamide → 2,6-dioxo-N-(carboxymethyl)morpholine

HRID 1262804

반응식

HRID 1262804 반응식
CN(C)C=O.C(OC(=O)C)(=O)C.[N:13]([CH2:22][C:23]([OH:25])=[O:24])([CH2:18][C:19]([OH:21])=O)[CH2:14][C:15]([OH:17])=[O:16]>N1C=CC=CC=1>[O:24]=[C:23]1[O:25][C:19](=[O:21])[CH2:18][N:13]([CH2:14][C:15]([OH:17])=[O:16])[CH2:22]1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 7918Acetic AnhydrideHCID 8758Nitrilotriacetic Acid

생성물 1

HCID 1695312,6-dioxo-N-(carboxymethyl)morpholine

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A round bottom flask is charged with dimethylformamide 72 g, acetic anhydride 25 g, pyridine 2 g, and nitrilotriacetic acid 38.2 g and the suspension is nitrogen purged for several minutes. The flask is stoppered and the mixture is stirred at room temperature for 3 days. A small amount of unreacted NTA is filtered out. The bulk of the solvent 79 ml is removed in vacuo at a bath temperature of 60°-70° C. The resulting viscous solution is twice roto-vacued after two successive additions of 40 ml dimethylformamide.

후처리

  1. custompurged for several minutes
  2. filtrationA small amount of unreacted NTA is filtered out
  3. customThe bulk of the solvent 79 ml is removed in vacuo at a bath temperature of 60°-70° C

출처 및 근거

ORD 기록
ord-d939aa6022c844578f13e673c4c67748
출처 데이터셋
uspto-grants-1984_06
특허 번호
US04454107

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