Bromine → 2-Bromo-4-(hydroxymethyl)-2,4-dimethyl-3-pentanone

HRID 1262989

반응식

HRID 1262989 반응식
[OH:1][CH2:2][C:3]([CH3:10])([CH3:9])[C:4](=[O:8])[CH:5]([CH3:7])[CH3:6].[Br:11]Br>C(Cl)(Cl)Cl>[Br:11][C:5]([CH3:7])([CH3:6])[C:4](=[O:8])[C:3]([CH3:10])([CH3:9])[CH2:2][OH:1]

참가 물질

4

반응물 2

HCID 24408BromineHCID 5191913-Pentanone, 1-hydroxy-2,2,4-trimethyl-

생성물 1

HCID 137335652-Bromo-4-(hydroxymethyl)-2,4-dimethyl-3-pentanone

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

To a stirred, refluxing solution of 69 g. (0.48 mole) of 1-hydroxy-2,2,4-trimethylpentan-3-one in 500 ml. of chloroform was added dropwise a solution of 77 g. (0.48 mole) bromine in 100 ml. of chloroform. When the addition was completed the mixture was stirred at reflux for one hour, allowed to cool and stand overnight at room temperature. Evaporation of solvent at reduced pressure afforded 127 g. of product which was used in the next step without purification.

후처리

  1. temperatureTo a stirred, refluxing solution of 69 g
  2. additionWhen the addition
  3. temperatureat reflux for one hour
  4. temperatureto cool
  5. customEvaporation of solvent at reduced pressure
  6. customafforded 127 g
  7. customof product which was used in the next step without purification

출처 및 근거

ORD 기록
ord-3f68d9a842cd428c80c4d35f17fb0c7a
출처 데이터셋
uspto-grants-1984_06
특허 번호
US04454328

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