Sodium borohydride → 6-(1-Hydroxy-4-chlorobutyl)-3,4-dihydrocarbostyril

HRID 1263101노트

반응식

HRID 1263101 반응식
[O:1]=[C:2]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH2:11][CH2:10]2)[CH2:3][CH2:4][CH2:5][Cl:6].[BH4-].[Na+]>CO>[OH:1][CH:2]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH2:11][CH2:10]2)[CH2:3][CH2:4][CH2:5][Cl:6]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 128335166-(4-Chlorobutyryl)-3,4-dihydrocarbostyril

생성물 1

HCID 128335136-(1-Hydroxy-4-chlorobutyl)-3,4-dihydrocarbostyril

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2.0 Grams of 6-(1-oxo-4-chlorobutyl)-3,4-dihydrocarbostyril was mixed with 100 ml of methanol, and the mixture was stirred at a room temperature. Then 1.0 g of sodium borohydride was added to the mixture gradually. After the reaction mixture was stirred at a room temperature for 2 hours, methanol was removed by distillation under a reduced pressure. The residue was extracted with chloroform and the chloroform layer was washed with water, and dried. Chloroform was removed by distillation under a reduced pressure, then the residue thus obtained was recrystallized from ethanol-water to obtain 1.2 g of 6-(1-hydroxy-4-chlorobutyl)-3,4-dihydrocarbostyril in colorless needle-like crystals. Melting point: 120°-121° C.

후처리

  1. stirringAfter the reaction mixture was stirred at a room temperature for 2 hours
  2. custommethanol was removed by distillation under a reduced pressure
  3. extractionThe residue was extracted with chloroform
  4. washthe chloroform layer was washed with water
  5. customdried
  6. customChloroform was removed by distillation under a reduced pressure
  7. customthe residue thus obtained
  8. customwas recrystallized from ethanol-water

출처 및 근거

ORD 기록
ord-6824de05d43d4c33b3a561986ac35802
출처 데이터셋
uspto-grants-1984_06
특허 번호
US04455422

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