Hydrogen Bromide → 4-[4-(2-Thiazolyl)-1-piperazinyl]phenol

반응식

CO[CH:3]1[S:7][C:6]([N:8]2[CH2:13][CH2:12][N:11]([C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=3)[CH2:10][CH2:9]2)=[N:5][CH2:4]1.Br>>[S:7]1[CH:3]=[CH:4][N:5]=[C:6]1[N:8]1[CH2:9][CH2:10][N:11]([C:14]2[CH:15]=[CH:16][C:17]([OH:20])=[CH:18][CH:19]=2)[CH2:12][CH2:13]1

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 12952783HCID 12952783, 화합물

생성물 1

HCID 129527844-[4-(2-Thiazolyl)-1-piperazinyl]phenol수율 68%

실험 절차

A mixture of 4 parts of 4-[4-(4,5-dihydro-5-methoxy-2-thiazolyl)-1-piperazinyl]phenol and 150 parts of a hydrobromic acid solution 48% is stirred and refluxed for 12 hours. The reaction mixture is evaporated and the residue is dissolved in water. The precipitated product is filtered off and crystallized from 4-methyl-2-pentanone. The product is filtered off and dried, yielding 2.5 parts (68%) of 4-[4-(2-thiazolyl)-1-piperazinyl]phenol; mp. 169.9° C.

후처리

temperaturerefluxed for 12 hours
customThe reaction mixture is evaporated
dissolutionthe residue is dissolved in water
filtrationThe precipitated product is filtered off
customcrystallized from 4-methyl-2-pentanone
filtrationThe product is filtered off
customdried

출처 및 근거

ORD 기록: ord-27242add97ee439789fdd5b0155bf0b4
출처 데이터셋: uspto-grants-1984_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04456605

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