1,2-Dichloroethane → HCID 18616028, 화합물

HRID 1263412노트

반응식

HRID 1263412 반응식
[CH3:1][NH:2][C:3]1[S:4][C:5]2[CH:11]=[CH:10][C:9]([C:12]([OH:14])=[O:13])=[C:8]([CH3:15])[C:6]=2[N:7]=1.[CH3:16][N:17]1[C:21](O)=[CH:20][CH:19]=[N:18]1.C(#N)C.C(Cl)CCl>CN(C1C=CN=CC=1)C.O.C(N(CC)CC)C>[CH3:1][NH:2][C:3]1[S:4][C:5]2[CH:11]=[CH:10][C:9]([C:12]([O:14][C:21]3[N:17]([CH3:16])[N:18]=[CH:19][CH:20]=3)=[O:13])=[C:8]([CH3:15])[C:6]=2[N:7]=1

참가 물질

8

반응물 4

HCID 111,2-DichloroethaneHCID 6342AcetonitrileHCID 186160494-Methyl-2-(methylamino)-1,3-benzothiazole-5-carboxylic acidHCID 178481816HCID 178481816, 화합물

생성물 1

HCID 18616028HCID 18616028, 화합물

시약·촉매·용매 3

HCID 142844-(Dimethylamino)pyridine촉매HCID 962Water용매HCID 8471Triethylamine용매

실험 절차

3.1 g of 2-methylamino-4-methylbenzothiazole-5-carboxylic acid (0.014 mol) and 1.4 g of 1-methyl-5-hydroxypyrazole (0.015 mol) were dissolved in 110 ml of abs. acetonitrile and admixed with 2.67 g of EDC (0.014 mol), 1,2 ml of triethylamine and a catalytic amount of DMAP. After the reaction had ended, the solution was poured into water and the mixture was extracted with ethyl acetate. The organic phase was washed and dried, and the product was then purified by crystallization. Yield: 2.2 g (52%).

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic phase was washed
  3. customdried
  4. customthe product was then purified by crystallization

출처 및 근거

ORD 기록
ord-293ef6d524064eb3bf4c40e69bbc5979
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06541423B1

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