Water → 1-Ethenyl-2-(iodomethyl)benzene

HRID 1264541

반응식

HRID 1264541 반응식
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]=[CH2:10].[I-:11].[Na+].O>CC(C)=O>[I:11][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]=[CH2:10]

참가 물질

5

반응물 3

HCID 962WaterHCID 5238Sodium IodideHCID 897571-(Chloromethyl)-2-ethenylbenzene

생성물 1

HCID 158305741-Ethenyl-2-(iodomethyl)benzene수율 95%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Dissolve 1-chloromethyl-2-vinyl-benzene (4.0 g, 26 mmol) in acetone (100 mL) and add sodium iodide (4.5 g, 30 mmol). Heat at gentle reflux for 30 minutes. Cool, add water (150 mL) and extract with pentane (200 mL). Dry (MgSO4) and evaporate the solvent in vacuo to give 1-iodomethyl-2-vinyl-benzene (95%).

후처리

  1. temperatureHeat
  2. temperatureat gentle reflux for 30 minutes
  3. temperatureCool
  4. extractionextract with pentane (200 mL)
  5. dry with materialDry (MgSO4)
  6. customevaporate the solvent in vacuo

출처 및 근거

ORD 기록
ord-62360d8ce7814f55b21d359d07ada96b
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06544980B2

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