Hydrogen Bromide → 5-Bromomethyl-2-pyridone

HRID 1264556노트

반응식

HRID 1264556 반응식
O[CH2:2][C:3]1[CH:4]=[CH:5][C:6](=[O:9])[NH:7][CH:8]=1.[BrH:10]>>[Br:10][CH2:2][C:3]1[CH:4]=[CH:5][C:6](=[O:9])[NH:7][CH:8]=1

참가 물질

3

반응물 2

HCID 260Hydrogen BromideHCID 120185765-(hydroxymethyl)pyridin-2(1H)-one

생성물 1

HCID 120185775-Bromomethyl-2-pyridone

반응 조건

온도
100 °C

실험 절차

To 5-hydroxymethyl-2-pyridone-(114.9 mg, 0.9 mmol) was added 3.0 ml of 48% hydrobromic acid. The mixture was heated at 100° C. for 20 minutes. The excess hydrobromic acid was then evaporated in vacuo to give the corresponding 5-bromomethyl-2-pyridone. This compound was used without purification. HRMS: m/e, M+ found; 186.9626, 7.4% Calc. for C6H6BrNO: 186.9633, −3.9 ppm.

후처리

  1. customThe excess hydrobromic acid was then evaporated in vacuo

출처 및 근거

ORD 기록
ord-23fb17d6d33847b483f80f9e1eb33301
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06544986B2

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