Phosphorus oxychloride → HCID 18613833, 화합물

HRID 1264964노트

반응식

[F:1][C:2]([F:27])([F:26])[C:3]1[CH:25]=[CH:24][C:6]([C:7]([NH:9][CH2:10][C:11]([C:13]2[CH:23]=[CH:22][C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:15][CH:14]=2)=O)=[O:8])=[CH:5][CH:4]=1.P(Cl)(Cl)(Cl)=O>>[F:27][C:2]([F:1])([F:26])[C:3]1[CH:4]=[CH:5][C:6]([C:7]2[O:8][C:11]([C:13]3[CH:23]=[CH:22][C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:15][CH:14]=3)=[CH:10][N:9]=2)=[CH:24][CH:25]=1

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 18613818HCID 18613818, 화합물

생성물 1

HCID 18613833HCID 18613833, 화합물수율 60%

실험 절차

In the same manner as in Example 106, ethyl 4-[2-(4-trifluoromethylbenzoylamino)-1-oxoethyl]benzoate was reacted with phosphorus oxychloride to obtain ethyl 4-[2-(4-trifluoromethylphenyl)-5-oxazolyl]benzoate. The product was recrystallized from ethanol. Yield: 60%. Pale yellow prisms. Melting point: 142 to 143° C.

출처 및 근거

ORD 기록: ord-3c0d160843994acabf5f2417375e7439
출처 데이터셋: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06545009B1

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