Chlorosuccinimide → HCID 69687567, 화합물

HRID 1265591

반응식

HRID 1265591 반응식
[CH3:1][O:2][CH2:3][C:4]1[CH:8]=[C:7]([C:9]2[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=2)[C:12]([O:14]C)=O)[O:6][N:5]=1.C(C1C=C(C=CC=1)C(OCC)=O)#C.C1C(=O)N(Cl)C(=O)C1.COCC=NO.[C:46]([O:49][C:50]([CH3:53])([CH3:52])[CH3:51])(=[O:48])[CH3:47].[Li]>C(Cl)(Cl)Cl.N1C=CC=CC=1.CCN(CC)CC>[C:50]([O:49][C:46](=[O:48])[CH2:47][C:12]([C:11]1[CH:16]=[CH:17][CH:18]=[C:9]([C:7]2[O:6][N:5]=[C:4]([CH2:3][O:2][CH3:1])[CH:8]=2)[CH:10]=1)=[O:14])([CH3:53])([CH3:52])[CH3:51]

참가 물질

9

반응물 5

HCID 31398ChlorosuccinimideHCID 15540684Ethyl 3-ethynylbenzoateHCID 18548718HCID 18548718, 화합물HCID 73450284HCID 73450284, 화합물HCID 86586795Lithium Tert-butyl Acetate

생성물 1

HCID 69687567HCID 69687567, 화합물

시약·촉매·용매 3

HCID 1049Pyridine용매HCID 6212Chloroform용매HCID 8471Triethylamine용매

실험 절차

The title compound was prepared from methyl 3-(3-methoxymethyl-isoxazol-5-yl)-benzoate [prepared by reaction of ethyl 3-ethynylbenzoate [CAS-No. 178742-95-5] with a mixture of NCS, 2-methoxyacetaldoxime [CAS-No. 71494-93-4], Et3N and cat. amount of pyridine in CHCl3 at 50° C. according to Tetrahedron 1984, 40, 2985-2988] by treatment with lithium tert.-butyl acetate according to general procedure K (method b). Obtained as a light yellow liquid (1.548 g).

후처리

  1. customat 50° C.

출처 및 근거

ORD 기록
ord-369ae7ed22f04edd8f0f1357deacb4c2
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06544985B2

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