N-bromobutanimide → 3-(5-Bromomethyl-thiazol-4-yl)-benzoic acid methyl ester

HRID 1265634노트

반응식

HRID 1265634 반응식
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[CH:12][S:13][C:14]=2[CH3:15])[CH:5]=1.[Br:17]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[CH:12][S:13][C:14]=2[CH2:15][Br:17])[CH:5]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 696892723-(5-Methyl-thiazol-4-yl)-benzoic acid methyl ester

생성물 1

HCID 696877023-(5-Bromomethyl-thiazol-4-yl)-benzoic acid methyl ester수율 104.6%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A mixture of 3-(5-methyl-thiazol-4-yl)-benzoic acid methyl ester (2.40 g), N-bromosuccinimid (2.01 g) and α,α′-bis(isobutyronitrile) (0.02 g) in CCl4 (40 mL) was heated at reflux for 30 min. The cooled mixture was filtered and the solvent was evaporated to give crude 3-(5-bromomethyl-thiazol-4-yl)-benzoic acid methyl ester (3.36 g) as an oil.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 30 min
  3. filtrationThe cooled mixture was filtered
  4. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-c17ef2d957ae41fcace9579ab5b3c222
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06544985B2

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