Sodium Hydroxide → N,N-bis(2,3-epoxypropyl)glycine

HRID 1266노트

반응식

HRID 1266 반응식
Cl[CH2:2][CH:3]([OH:15])[CH2:4][N:5]([CH2:10][CH:11]([OH:14])[CH2:12]Cl)[CH2:6][C:7]([OH:9])=[O:8].[Na].[OH-].[Na+]>O>[O:14]1[CH2:12][CH:11]1[CH2:10][N:5]([CH2:4][CH:3]1[O:15][CH2:2]1)[CH2:6][C:7]([OH:9])=[O:8]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86752178sodium N,N-bis(3-chloro-2-hydroxypropyl)glycine

생성물 1

HCID 19695060N,N-bis(2,3-epoxypropyl)glycine수율 84%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A reactor was charged with 20 g (0.07 mole) of sodium N,N-bis(3-chloro-2-hydroxypropyl)glycine obtained in the same manner as in Referential Example 1 and 100 g of water, and the contents were kept at 50° C., to which 35 ml of a 4N aqueous solution of sodium hydroxide were added. After the mixture was stirred for 30 minutes, the solvent was distilled off under reduced pressure, and 100 ml of ethanol were added to the residue to separate insoluble matter by filtration. Thereafter, ethanol was distilled off under reduced pressure, thereby obtaining 11 g (isolation yield: 84%) of N,N-bis(2,3-epoxypropyl)glycine.

후처리

  1. additionwere added
  2. distillationthe solvent was distilled off under reduced pressure, and 100 ml of ethanol
  3. additionwere added to the residue
  4. customto separate insoluble matter
  5. filtrationby filtration
  6. distillationThereafter, ethanol was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-f88ac48b7e45476aa2b72c1493bc7762
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723655

반응 노트

불러오는 중…