Hydrochloric Acid → HCID 178418386, 화합물

HRID 1266152

반응식

HRID 1266152 반응식
[O:1]=[C:2]([CH2:8][C:9](=[O:19])[C:10]1[C:15]([CH3:16])=[CH:14][C:13]([CH3:17])=[CH:12][C:11]=1[CH3:18])[C:3]([O:5][CH2:6][CH3:7])=[O:4].Cl.[N:21]([O-])=[O:22].[Na+]>C(O)C>[O:1]=[C:2]([C:8](=[N:21][OH:22])[C:9](=[O:19])[C:10]1[C:11]([CH3:18])=[CH:12][C:13]([CH3:17])=[CH:14][C:15]=1[CH3:16])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14945000Ethyl 2,4-dioxo-4-(2,4,6-trimethylphenyl)butanoateHCID 23668193Sodium Nitrite

생성물 1

HCID 178418386HCID 178418386, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

N2O3 gas was slowly passed into a stirred solution of the product of step A (16.2 g) in 300 mL of ethanol until the disappearance of starting material was confirmed by TLC. N2O3 gas was generated by the dropwise addition of 12 N aqueous HCl solution into an aqueous slurry of NaNO2. The solvent was removed from the mixture and 200 mL of water was added to the residue. The product was then extracted into ether. The ether extract was dried over Na2SO4 and evaporated to give 16.1 g of a semi-solid.

후처리

  1. customThe solvent was removed from the mixture and 200 mL of water
  2. additionwas added to the residue
  3. extractionThe product was then extracted into ether
  4. extractionThe ether extract
  5. dry with materialwas dried over Na2SO4
  6. customevaporated

출처 및 근거

ORD 기록
ord-12da3de273734e1aa40c4bcd66fd269e
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06548509B2

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