Hydrazine hydrate (1:1) → 2-Hydrazino-6-(4-trifluoromethylphenoxy)pyridine

HRID 1266922

반응식

HRID 1266922 반응식
F[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:3]=1.O.[NH2:20][NH2:21]>C(O)C>[NH:20]([C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:3]=1)[NH2:21]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 185447832-Fluoro-6-(4-trifluoromethylphenoxy)pyridine

생성물 1

HCID 185447862-Hydrazino-6-(4-trifluoromethylphenoxy)pyridine수율 47.8%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
40 °C

실험 절차

Next, a reaction flask was loaded with 2-fluoro-6-(4-trifluoromethylphenoxy)pyridine (8.0 g) and ethanol (60 ml), and heated up to 40° C. with stirring. To this mixture, hydrazine monohydrate (7.6 g) was dropwise added in 30 minutes. The temperature of the mixture was raised to the reflux temperature, followed by stirring for 20 hours. Thereafter, the heating was stopped, and the reaction mixture was cooled, followed by filtration to remove insoluble components. The filtrate was condensed by an evaporator to give 2-hydrazino-6-(4-trifluoromethylphenoxy)pyridine (4.0 g).

후처리

  1. temperatureThe temperature of the mixture was raised to the reflux temperature
  2. stirringby stirring for 20 hours
  3. temperaturethe reaction mixture was cooled
  4. filtrationfollowed by filtration
  5. customto remove insoluble components
  6. customcondensed
  7. customby an evaporator

출처 및 근거

ORD 기록
ord-172563bbfa8c4f0e8db9a9212f308f10
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06551682B1

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