Hydrazine hydrate (1:1) → HCID 18544800, 화합물

HRID 1266928노트

반응식

HRID 1266928 반응식
F[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[C:6]([O:12][CH3:13])[N:5]=[C:4]([CH3:14])[N:3]=1.O.[NH2:16][NH2:17]>C(O)C>[NH:16]([C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[C:6]([O:12][CH3:13])[N:5]=[C:4]([CH3:14])[N:3]=1)[NH2:17]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 133793024-Fluoro-6-methoxy-2-methyl-5-(trifluoromethyl)pyrimidine

생성물 1

HCID 18544800HCID 18544800, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Next, a reaction flask was loaded with 4-fluoro-6-methoxy-2-methyl-5-(trifluoromethyl)-pyrimidine (22 g) and ethanol (40 ml), followed by dropwise addition of hydrazine monohydrate (10.5 g) to the flask in one hour with stirring. Then, after stirring for one hour, the reaction mixture was filtrated to give 4-hydrazino-6-methoxy-2-methyl-5-(trifluoromethyl)pyrimidine. By GC/MS analysis, a molecular ion peak of 222 was confirmed for this compound.

후처리

  1. stirringThen, after stirring for one hour
  2. filtrationthe reaction mixture was filtrated

출처 및 근거

ORD 기록
ord-ef40c0aa281a4cbc8861ef1eea4bd4f1
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06551682B1

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