Hydrochloric Acid → 2-Oxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile

HRID 1267154노트

반응식

HRID 1267154 반응식
C([O:3][C:4](=O)[CH2:5][N:6]([C:14]1[CH:19]=[C:18]([C:20]#[N:21])[CH:17]=[CH:16][C:15]=1[NH2:22])C(OC(C)(C)C)=O)C.Cl.CCOCC>CO.O1CCOCC1>[C:20]([C:18]1[CH:19]=[C:14]2[C:15](=[CH:16][CH:17]=1)[NH:22][C:4](=[O:3])[CH2:5][NH:6]2)#[N:21]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 69839618HCID 69839618, 화합물

생성물 1

HCID 185457712-Oxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile수율 99%

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

N-Boc-2-amino-5-cyanophenylglycin ethyl ester (2.6 g, 8.17 mmol) in MeOH (20 mL) was treated with 4M HCl in dioxane (20 mL) at rt for 16 hours. To the mixture was added Et2O until no more solid appeared. The solid was collected, washed with Et2O, and dried by air to give the product (1.4 g, 82%). 1H NMR (CD3COCD3) δ 7.02 (d, J=8.4 Hz, 1H), 7.00 (d, J=1.8 Hz, 1H), 6.95 (d, J=8.4 Hz, 1H), 3.89 (s, 2H).

후처리

  1. customThe solid was collected
  2. washwashed with Et2O
  3. customdried by air

출처 및 근거

ORD 기록
ord-2ba1725105f24295a2b8f2e0e81d9bbd
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06552042B2

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