2,6-Diphenylpyridine → (R)-N-[3-nitro-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

HRID 1267731

반응식

HRID 1267731 반응식
[OH:1][C@@:2]([CH3:10])([C:6]([F:9])([F:8])[F:7])[C:3](O)=[O:4].[Cl:11][C:12]1[C:18]([N+:19]([O-:21])=[O:20])=[CH:17][CH:16]=[CH:15][C:13]=1[NH2:14].C1(C2C=CC=C(C3C=CC=CC=3)N=2)C=CC=CC=1>>[N+:19]([C:18]1[C:12]([Cl:11])=[C:13]([NH:14][C:3](=[O:4])[C@:2]([OH:1])([CH3:10])[C:6]([F:9])([F:8])[F:7])[CH:15]=[CH:16][CH:17]=1)([O-:21])=[O:20]

참가 물질

4

반응물 3

HCID 729202,6-DiphenylpyridineHCID 2760712(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acidHCID 142200162-Chloro-3-nitroaniline

생성물 1

HCID 58964771(R)-N-[3-nitro-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

실험 절차

The title compound was prepared by the method of Example 6 using (R)-(+)-2-hydroxy-2-methyl-3,3,3-trifluoropropanoic acid (Method 3) and 2-chloro-3-nitroaniline (Tetrahedron, 1999, 56 (2), 165-173) except that 2,6-diphenylpyridine was used instead of 2,6-di-t-butylpyridine. NMR (CDCl3) 1.77 (s, 3H), 3.58 (s, 1H), 7.44 (t, 1H), 7.63 (d, 1H), 8.66 (d, 1H), 9.27 (s, 1H); m/z 311.

출처 및 근거

ORD 기록
ord-de58347e36eb4e578562f5ea0378103f
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06552225B1

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