Methyl bromoacetate → [tert-Butoxycarbonyl-(3,4-difluorophenyl)-amino]-acetic acid methyl ester

HRID 1267908노트

반응식

HRID 1267908 반응식
[C:1]([O:5][C:6](=[O:16])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([F:14])=[C:10]([F:15])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].CC(C)([O-])C.[K+].Br[CH2:24][C:25]([O:27][CH3:28])=[O:26]>O1CCCC1>[CH3:28][O:27][C:25](=[O:26])[CH2:24][N:7]([C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:16])[C:8]1[CH:13]=[CH:12][C:11]([F:14])=[C:10]([F:15])[CH:9]=1

참가 물질

5

반응물 3

HCID 60984Methyl bromoacetateHCID 2783369Carbamic acid, (3,4-difluorophenyl)-, 1,1-dimethylethyl esterHCID 23665647Potassium tert-butoxide

생성물 1

HCID 54030684[tert-Butoxycarbonyl-(3,4-difluorophenyl)-amino]-acetic acid methyl ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of (3,4-difluorophenyl)-carbamic acid tert-butyl ester (Tetrahedron, (1992), 48(35), 7373) (15.1 g) in tetrahydrofuran (120 ml) at 0° C. was added potassium tert-butoxide (94 ml of a 1.0 M solution in tetrahydrofuran) dropwise. After stirring for 2 hr methyl bromoacetate (9.1 ml) was added dropwise and ice-bath removed and reaction mixture stirred at room temperature overnight. Reaction mixture concentrated under reduced pressure, diluted with ethyl acetate and washed with water and brine, dried (Na2SO4) and concentrated to leave the sub-title compound as a brown oil (18.0 g).

후처리

  1. additionwas added dropwise
  2. customice-bath removed
  3. customreaction mixture
  4. customReaction mixture
  5. concentrationconcentrated under reduced pressure
  6. additiondiluted with ethyl acetate
  7. washwashed with water and brine
  8. dry with materialdried (Na2SO4)
  9. concentrationconcentrated

출처 및 근거

ORD 기록
ord-302bd5a608e94b5ca6ff9967c6d1887a
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06555541B1

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