Acetic Anhydride → 10-Acetoxy-5,5-dimethyl-8-(3-methyl-2-octyl)-5H-[1]benzopyrano[3,4-d]pyridine

HRID 126797

반응식

HRID 126797 반응식
[CH3:1][C:2]1([CH3:26])[C:21]2=[CH:22][CH:23]=[N:24][CH:25]=[C:20]2[C:5]2[C:6]([OH:19])=[CH:7][C:8]([CH:10]([CH:12]([CH3:18])[CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH3:11])=[CH:9][C:4]=2[O:3]1.[C:27](OC(=O)C)(=[O:29])[CH3:28]>N1C=CC=CC=1>[C:27]([O:19][C:6]1[C:5]2[C:20]3[C:21]([C:2]([CH3:1])([CH3:26])[O:3][C:4]=2[CH:9]=[C:8]([CH:10]([CH:12]([CH3:18])[CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH3:11])[CH:7]=1)=[CH:22][CH:23]=[N:24][CH:25]=3)(=[O:29])[CH3:28]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 197814025,5-Dimethyl-10-hydroxy-8-(3-methyl-2-octyl)-5H-[1]benzopyrano[3,4-d]pyridine

생성물 1

HCID 2028784710-Acetoxy-5,5-dimethyl-8-(3-methyl-2-octyl)-5H-[1]benzopyrano[3,4-d]pyridine

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A mixture of 3.53 g. (0.01 mole) of 5,5-dimethyl-10-hydroxy-8-(3-methyl-2-octyl)-5H-[1]benzopyrano[3,4-d]pyridine, 1.22 g. (0.012 mole) of acetic anhydride, and 5 ml. of pyridine was stirred at room temperature for 24 hours. The reaction mixture was evaporated in vacuo, and the residue was taken up in ether. The ether solution was washed with water, dried with anhydrous sodium sulfate, and evaporated in vacuo. The residue was purified by chromatography on a Florosil® activated aluminum magnesium silicate 22 mm×30 inch column with chloroform to give the pure product.

후처리

  1. additionA mixture of 3.53 g
  2. customThe reaction mixture was evaporated in vacuo
  3. washThe ether solution was washed with water
  4. dry with materialdried with anhydrous sodium sulfate
  5. customevaporated in vacuo
  6. customThe residue was purified by chromatography on a Florosil® activated aluminum magnesium silicate 22 mm×30 inch column with chloroform
  7. customto give the pure product

출처 및 근거

ORD 기록
ord-088bf249f04d472f82e640deba12184c
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04254116

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