Nitric Acid → 2-Isopropyl-4-nitrophenol
반응식
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([CH3:3])[CH3:2].[N+:11]([O-])([OH:13])=[O:12].O>C(O)(=O)C>[CH:1]([C:4]1[CH:9]=[C:8]([N+:11]([O-:13])=[O:12])[CH:7]=[CH:6][C:5]=1[OH:10])([CH3:3])[CH3:2]참가 물질
5
실험 절차
To a solution of 2-isopropylphenol (4.1 ml) in acetic acid (30 ml) was added 69% nitric acid (4 ml) in an ice bath and the mixture was stirred at the same temperature for 30 minutes. After addition of iced water, the reaction mixture was extracted with t-butyl methyl ether. The extractant was washed with water and brine, dried over anhydrous sodium sulfate, filtered and the filtrate concentrated in vacuo. The residue was purified by chromatography on a silica gel column using hexane/ethyl acetate=4/1 as an eluant to give the desired compound (2.66 g, yield 49%) as a yellow solid.
후처리
- extractionthe reaction mixture was extracted with t-butyl methyl ether
- washThe extractant was washed with water and brine
- dry with materialdried over anhydrous sodium sulfate
- filtrationfiltered
- concentrationthe filtrate concentrated in vacuo
- customThe residue was purified by chromatography on a silica gel column
출처 및 근거
- ORD 기록
- ord-425b21d7ec7e4456bab2528b0a34dd38
- 출처 데이터셋
- uspto-grants-2003_04
- 특허 번호
- US06555556B1
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