Hydrogen Bromide → 1-(3-bromopropyl)-5,6-dichloro-1,3-dihydro-2H-benzimidazol-2-one
반응식
[Cl:1][C:2]1[C:15]([Cl:16])=[CH:14][C:5]2[N:6]([CH2:10][CH2:11][CH2:12]O)[C:7](=[O:9])[NH:8][C:4]=2[CH:3]=1.[BrH:17]>O>[Br:17][CH2:12][CH2:11][CH2:10][N:6]1[C:5]2[CH:14]=[C:15]([Cl:16])[C:2]([Cl:1])=[CH:3][C:4]=2[NH:8][C:7]1=[O:9]참가 물질
4
실험 절차
A mixture of 57.5 parts of 5,6-dichloro-1,3-dihydro-1-(3-hydroxypropyl)-2H-benzimidazol-2-one and 450 parts of a hydrobromic acid solution 48% in water is stirred and refluxed for 2.50 hours. The reaction mixture is cooled and water is added. The precipitated product is filtered off, stirred in 700 parts of water, filtered off again and dried in vacuo, yielding 59 parts (81%) of 1-(3-bromopropyl)-5,6-dichloro-1,3-dihydro-2H-benzimidazol-2-one; mp. 198.1° C.
후처리
- temperaturerefluxed for 2.50 hours
- temperatureThe reaction mixture is cooled
- filtrationThe precipitated product is filtered off
- stirringstirred in 700 parts of water
- filtrationfiltered off again
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-af68619533ab484c9d2788f36e347762
- 출처 데이터셋
- uspto-grants-1981_03
- 특허 번호
- US04254127
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