Acetic Anhydride → Ethyl 1-acetyl-4-piperidineacetate

HRID 126856

반응식

HRID 126856 반응식
[C:1](OC(=O)C)(=[O:3])[CH3:2].[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10][CH2:9]1>CC1C=CC=CC=1>[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10][CH2:9]1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 2760465Ethyl 2-(piperidin-4-yl)acetate

생성물 1

HCID 54363171Ethyl 1-acetyl-4-piperidineacetate수율 82%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 200 parts of acetic acid anhydride, 90 parts of ethyl 4-piperidineacetate and 225 parts of methylbenzene is stirred and refluxed for 3 hours. The reaction mixture is evaporated and the residue is diluted with water. The product is extracted with methylbenzene. The extract is dried, filtered and evaporated, yielding 92 parts (82%) of ethyl 1-acetyl-4-piperidineacetate as a residue.

후처리

  1. temperaturerefluxed for 3 hours
  2. customThe reaction mixture is evaporated
  3. additionthe residue is diluted with water
  4. extractionThe product is extracted with methylbenzene
  5. customThe extract is dried
  6. filtrationfiltered
  7. customevaporated

출처 및 근거

ORD 기록
ord-3738f18a6d774f939670885c325dad30
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04254127

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