Acetic Anhydride → Ethyl 1-acetyl-4-piperidineacetate
반응식
[C:1](OC(=O)C)(=[O:3])[CH3:2].[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10][CH2:9]1>CC1C=CC=CC=1>[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10][CH2:9]1)(=[O:3])[CH3:2]참가 물질
4
실험 절차
A mixture of 200 parts of acetic acid anhydride, 90 parts of ethyl 4-piperidineacetate and 225 parts of methylbenzene is stirred and refluxed for 3 hours. The reaction mixture is evaporated and the residue is diluted with water. The product is extracted with methylbenzene. The extract is dried, filtered and evaporated, yielding 92 parts (82%) of ethyl 1-acetyl-4-piperidineacetate as a residue.
후처리
- temperaturerefluxed for 3 hours
- customThe reaction mixture is evaporated
- additionthe residue is diluted with water
- extractionThe product is extracted with methylbenzene
- customThe extract is dried
- filtrationfiltered
- customevaporated
출처 및 근거
- ORD 기록
- ord-3738f18a6d774f939670885c325dad30
- 출처 데이터셋
- uspto-grants-1981_03
- 특허 번호
- US04254127
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