2-Amino-4-methylpyridine → 2-(4-Bromophenyl)-7-methylimidazo[1,2-a]pyridine

HRID 1268685

반응식

HRID 1268685 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=O.[NH2:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]=1>C(O)C>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:12]=[C:13]3[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]3[CH:2]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 15332-Amino-4-methylpyridineHCID 74544-Bromophenacyl bromide

생성물 1

HCID 7176442-(4-Bromophenyl)-7-methylimidazo[1,2-a]pyridine수율 56.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2,4′-dibromoacetophenone (22.4 g) and 2-amino-4-picoline (8.68 g) in ethanol (80 mL) was heated at reflux temperature for 3 hours. The reaction mixture was cooled to ambient temperature and the crystalline solid-isolated by filtration, washed with ethanol and dried in vacuo to give the title compound (13.1 g).

후처리

  1. temperaturewas heated
  2. temperatureat reflux temperature for 3 hours
  3. customthe crystalline solid-isolated by filtration
  4. washwashed with ethanol
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-0eb7891d007242a3b2069e7540f271dc
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07199117B2

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