Hydrochloric Acid → Ethyl 2-chloro-2-ethoxyacetate
반응식
CO[CH2:3][CH2:4]OC.C(O)C.[ClH:10].[C:11]([O:15][CH2:16][CH3:17])(=[O:14])[CH:12]=[O:13]>O>[Cl:10][CH:12]([O:13][CH2:3][CH3:4])[C:11]([O:15][CH2:16][CH3:17])=[O:14]참가 물질
6
실험 절차
Into a mixture of 10 ml. of 1,2-dimethoxyethane and 5.8 ml. of ethanol is passed 3.65 g. hydrogen chloride gas with cooling. Then 10.2 g of ethyl glyoxylate is added and after 24 hours at 25° C., 200 ml. of water and ice is added. The mixture is then extracted several times with ether and the extracts dried over anhydrous sodium sulfate. After evaporation of the extracts to an oil, the ethyl α-chloro-α-ethoxy-acetate so formed is added to a stirred mixture of 35.0 g. of sodium 4-(hexadecylamino)benzoate in 125 ml. of hexamethylphosphoramide. After 24 hours at 20° C., the product is obtained as white crystals by careful addition of water.
후처리
- additionInto a mixture of 10 ml
- extractionThe mixture is then extracted several times with ether
- dry with materialthe extracts dried over anhydrous sodium sulfate
- customAfter evaporation of the extracts to an oil
출처 및 근거
- ORD 기록
- ord-366d262e502f480a8aabd130c51c6a61
- 출처 데이터셋
- uspto-grants-1981_03
- 특허 번호
- US04254138
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